Neuroscience

Biomedical

Microglia Heterogeneity in Alzheimer’s Disease: Insights From Single-Cell Technologies


Microglia are resident immune cells in the central nervous system and play critical roles in brain immunity, development, and homeostasis. The pathology of Alzheimer’s disease (AD) triggers activation of microglia. Microglia express many AD risk genes, suggesting that their response to AD pathology can affect disease progression. Microglia have long been considered a homogenous cell population. ...
2 months ago

Biomedical

Synaptic plasticity through a naturalistic lens


From the myriad of studies on neuronal plasticity, investigating its underlying molecular mechanisms up to its behavioral relevance, a very complex landscape has emerged. Recent efforts have been achieved toward more naturalistic investigations as an attempt to better capture the synaptic plasticity underpinning of learning and memory, which has been fostered by the development of in vivo electrop...
2 months ago

Biomedical

Optical Quantal Analysis


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2 months ago

Biomedical

Retromer in Synaptic Function and Pathology


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2 months ago

Biomedical

Modeling Neurological Diseases With Human Brain Organoids


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2 months ago

Biomedical

Gait and Cognitive Declines in Dementia—Double or Nothing


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2 months ago

Biomedical

Effects of Electroacupuncture for Depression-Related Insomnia


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2 months ago

Biomedical

Neural flip-flops I: Short-term memory


The networks proposed here show how neurons can be connected to form flip-flops, the basic building blocks in sequential logic systems. The novel neural flip-flops (NFFs) are explicit, dynamic, and can generate known phenomena of short-term memory. For each network design, all neurons, connections, and types of synapses are shown explicitly. The neurons’ operation depends only on explicitly stat...
2 months ago

Biomedical

Stochastic attractor models of visual working memory


This paper investigates models of working memory in which memory traces evolve according to stochastic attractor dynamics. These models have previously been shown to account for response-biases that are manifest across multiple trials of a visual working memory task. Here we adapt this approach by making the stable fixed points correspond to the multiple items to be remembered within a single-tria...
2 months ago

Biomedical

Is manual drawing of region of interest to measure fractional anisotropy a reliable method of determining white matter integrity- Medial Temporal Lobe Epilepsy model


In patients with Medial Temporal Lobe Epilepsy (MTLE), more severe impairment in the ipsilateral than the contralateral hemisphere white matter tracts, including Superior Longitudinal Fasciculus (SLF), are demonstrated on diffusion tensor imaging (DTI). Many clinicians and researchers conclude that drawing regions of interest (ROI) in the white matter can demonstrate these asymmetries. In this ...
2 years ago

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