Biochemistry

Biomedical

Electrochemical Synthesis of the In Human S-oxide Metabolites of Phenothiazine-Containing Antipsychotic Medications

Ridho Asra,

Ridho Asra

Institution: School of Pharmacy, Institute of Clinical Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK

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Aigul Erbosynovna Malmakova,

Aigul Erbosynovna Malmakova

Institution: School of Pharmacy, Institute of Clinical Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK

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Alan M. Jones

Alan M. Jones

Institution: School of Pharmacy, Institute of Clinical Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK

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Abstract

The tractable preparation of Phase I drug metabolites is a critical step to understand the first-pass behaviour of novel chemical entities (NCEs) in drug discovery. In this study, we have developed a structure–electroactivity relationship (SeAR)-informed electrochemical reaction of the parent 2-chlorophenothiazine and the ...
17 hours ago

Biomedical

What choanoflagellates can teach us about symbiosis

Arielle Woznica

Arielle Woznica

Institution:

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Summary

This study examines the relationship between carbon emissions and low-carbon innovation in firms using panel data from Chinese A-share listed companies from 2010 to 2019. The key findings include:

  • Carbon emissions promote low-carbon innovation in firms
  • This effect is mediated by carbon emissions reduction pressure...
    5 days ago

Biomedical

Selective Schiff Base Formation of Group 9 Organometallic Complexes with Functionalized Spirobifluorene Ligands

Krystal M. Cid-Seara,

Krystal M. Cid-Seara

Institution: Departamento de Química Inorgánica, Universidade de Vigo, Campus Universitario, 36310 Vigo, Spain

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Raquel Pereira-Cameselle,

Raquel Pereira-Cameselle

Institution: Departamento de Química Orgánica, Universidade de Vigo, Campus Universitario, 36310 Vigo, Spain

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Sandra Bolaño,

Sandra Bolaño

Institution: Departamento de Química Inorgánica, Universidade de Vigo, Campus Universitario, 36310 Vigo, Spain

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Maria Talavera

Maria Talavera

Institution: Departamento de Química Inorgánica, Universidade de Vigo, Campus Universitario, 36310 Vigo, Spain

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Organic amines are important compounds present in a wide variety of products, which makes the development of new systems for their detection an interesting field of study. New organometallic complexes of group 9 [MCp*X(2′-R-2-py-SBF)] (M = Ir, Rh; R = H, X = Cl (6), R = H, X = OAc (7), R = CHO, X = Cl (8)), and [IrCp*Cl(2′, 7-diCHO-2-py-SBF)] (9) (Cp* pentamethylcyclopentadienyl, SBF =...
2 weeks ago

Biomedical

Screening Canola Genotypes for Resistance to Ammonium Toxicity

Omar Ali Shaban Al-Awad,

Omar Ali Shaban Al-Awad

Institution: School of Agriculture and Environment, University of Western Australia, 35 Stirling Highway, Perth, WA 6009, Australia

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Kit Stasia Prendergast,

Kit Stasia Prendergast

Institution: School of Molecular and Life Sciences, Curtin University, Kent Street, Bentley, Perth, WA 6102, Australia

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Alan Robson,

Alan Robson

Institution: School of Agriculture and Environment, University of Western Australia, 35 Stirling Highway, Perth, WA 6009, Australia

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Zed Rengel

Zed Rengel

Institution: School of Agriculture and Environment, University of Western Australia, 35 Stirling Highway, Perth, WA 6009, Australia

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Soil ammonium toxicity can decrease plant growth, and many crop species have low resistance to ammonium, including canola, an economically important crop. Different genotypes may differ in their resistance to ammonium toxicity, and therefore determining if there are genotypes that exhibit variation in their ability to tolerate soil ammonium is a research priority. Here, we evaluate how soi...
1 month ago

Biomedical

Progress on Electrochemical Sensing of Pharmaceutical Drugs in Complex Biofluids

Elain Fu,

Elain Fu

Institution: School of Chemical, Biological and Environmental Engineering, Oregon State University, Corvallis, OR 97331, USA

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Khadijeh Khederlou,

Khadijeh Khederlou

Institution: School of Chemical, Biological and Environmental Engineering, Oregon State University, Corvallis, OR 97331, USA

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Noël Lefevre,

Noël Lefevre

Institution: School of Chemical, Biological and Environmental Engineering, Oregon State University, Corvallis, OR 97331, USA

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Stephen A. Ramsey,

Stephen A. Ramsey

Institution: School of Electrical Engineering and Computer Science, Oregon State University, Corvallis, OR 97331, USA

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Matthew L. Johnston,

Matthew L. Johnston

Institution: School of Electrical Engineering and Computer Science, Oregon State University, Corvallis, OR 97331, USA

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Lael Wentland

Lael Wentland

Institution: School of Chemical, Biological and Environmental Engineering, Oregon State University, Corvallis, OR 97331, USA

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Electrochemical detection, with its advantages of being rapid, multi-time point, compatible with cost-effective fabrication methods, and having the potential for miniaturization and portability, has great promise for point-of-care drug monitoring. However, a continuing challenge concerns the robust and sensitive electrochemical detection of pharmaceutical analytes from biological fluids. T...
1 month ago

Biomedical

Automated Patch Clamp for the Detection of Tetrodotoxin in Pufferfish Samples

Mònica Campàs,

Mònica Campàs

Institution: IRTA, Marine and Continental Waters (AMiC) Programme, Ctra. Poble Nou del Delta, km. 5.5, 43540 La Ràpita, Spain

Email:

Jaume Reverté,

Jaume Reverté

Institution: IRTA, Marine and Continental Waters (AMiC) Programme, Ctra. Poble Nou del Delta, km. 5.5, 43540 La Ràpita, Spain

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Àngels Tudó,

Àngels Tudó

Institution: Department of Basic Medical Sciences, Universitat Rovira i Virgili, C/Sant Llorenç 21, 43201 Reus, Spain

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Mounira Alkassar,

Mounira Alkassar

Institution: IRTA, Marine and Continental Waters (AMiC) Programme, Ctra. Poble Nou del Delta, km. 5.5, 43540 La Ràpita, Spain

Email:

Jorge Diogène,

Jorge Diogène

Institution: IRTA, Marine and Continental Waters (AMiC) Programme, Ctra. Poble Nou del Delta, km. 5.5, 43540 La Ràpita, Spain

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Francesc X. Sureda

Francesc X. Sureda

Institution: Department of Basic Medical Sciences, Universitat Rovira i Virgili, C/Sant Llorenç 21, 43201 Reus, Spain

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Tetrodotoxin (TTX) is a marine toxin responsible for many intoxications around the world. Its presence in some pufferfish species and, as recently reported, in shellfish, poses a serious health concern. Although TTX is not routinely monitored, there is a need for fast, sensitive, reliable, and simple methods for its detection and quantification. In this work, we describe the use of an auto...
1 month ago

Biomedical

Recent Advances in Metalloproteomics

James P. C. Coverdale,

James P. C. Coverdale

Institution: School of Pharmacy, Institute of Clinical Sciences, University of Birmingham, Edgbaston B15 2TT, UK

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Sirilata Polepalli,

Sirilata Polepalli

Institution: Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK

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Marco A. Z. Arruda,

Marco A. Z. Arruda

Institution: Institute of Chemistry, Department of Analytical Chemistry, Universidade Estadual de Campinas, Campinas 13083-970, Brazil

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Ana B. Santos da Silva,

Ana B. Santos da Silva

Institution: Institute of Chemistry, Department of Analytical Chemistry, Universidade Estadual de Campinas, Campinas 13083-970, Brazil

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Alan J. Stewart,

Alan J. Stewart

Institution: School of Medicine, University of St. Andrews, St Andrews KY16 9TF, UK

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Claudia A. Blindauer

Claudia A. Blindauer

Institution: Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK

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Interactions between proteins and metal ions and their complexes are important in many areas of the life sciences, including physiology, medicine, and toxicology. Despite the involvement of essential elements in all major processes necessary for sustaining life, metalloproteomes remain ill-defined. This is not only owing to the complexity of metalloproteomes, but also to the non-covalent c...
1 month ago

Biomedical

Kavalactone Kawain Impedes Urothelial Tumorigenesis in UPII-Mutant Ha-Ras Mice via Inhibition of mTOR Signaling and Alteration of Cancer Metabolism

Zhongbo Liu,

Zhongbo Liu

Institution: Department of Urology, University of California Irvine, Orange, CA 92868, USA

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Liankun Song,

Liankun Song

Institution: Department of Urology, University of California Irvine, Orange, CA 92868, USA

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Jun Xie,

Jun Xie

Institution: Department of Urology, University of California Irvine, Orange, CA 92868, USA

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Xue-Ru Wu,

Xue-Ru Wu

Institution: Department of Urology, NYU School of Medicine, New York, NY 10016, USA

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Greg E. Gin,

Greg E. Gin

Institution: Department of Urology, University of California Irvine, Orange, CA 92868, USA

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Beverly Wang,

Beverly Wang

Institution: Department of Pathology and Laboratory Medicine, University of California, Irvine, Orange, CA 92868, USA

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Edward Uchio,

Edward Uchio

Institution: Department of Urology, University of California Irvine, Orange, CA 92868, USA

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Xiaolin Zi

Xiaolin Zi

Institution: Department of Urology, University of California Irvine, Orange, CA 92868, USA

Email:


UPII-mutant Ha-ras transgenic mice develop urothelial hyperplasia and low-grade papillary carcinoma, which mimics human non-muscle invasive bladder cancer (NMIBC). We investigated the effects and mechanisms of kawain, a main kavalactone in the kava plant, on oncogenic Ha-ras-driven urothelial carcinoma in these mice. The mice were fed at six weeks of age with vehicle control or kawain (6 g...
1 month ago

Biomedical

Cell autocloning as a pathway to their real rejuvenation

Lev Salnikov

Lev Salnikov

Institution:

Email:


The article gives a brief description of geroprotection and rejuvenation methods known to date, presenting their main mechanisms and limitations. To overcome the main limitations of the process of rejuvenation, it is possible to use a process called “cell autocloning.” The principle of the proposed method of rejuvenation is as follows: a periodic process of autocloning of the cell nucleus is i...
1 month ago

Biomedical

The Challenge of Unlocking the Biological Secrets of Aging

Consuelo Borrás

Consuelo Borrás

Institution:

Email:


...
1 month ago

Related Subjects

Anatomy Epidemiology Genetics Neuroscience Psychology Oncology Medicine Musculoskeletal science Pediatrics Pathology Pharmacology Physiology Psychiatry Primary care Women and reproductive health

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