Institution: Department of Informatics, Faculty of Mathematics and Natural Sciences, South-West University, 2700 Blagoevgrad, Bulgaria
Email:
Radoslava Kraleva
Radoslava Kraleva
Institution: Department of Informatics, Faculty of Mathematics and Natural Sciences, South-West University, 2700 Blagoevgrad, Bulgaria
Email:
This research focuses on evolutionary algorithms, particularly genetic and memetic algorithms. The study examines a graph theory problem related to finding a minimal Hamiltonian cycle in a complete undirected graph (Travelling Salesman Problem-TSP). The paper presents implementations of two approximate algorithms for solving this problem: genetic and memetic. The main objective is to determine the...
2 weeks ago
Polygenic Risk Scores (PRS) (also known as polygenic scores, genetic risk scores or polygenic indexes) capture genetic contributions of a multitude of markers that characterise complex traits. Although their likely application to precision medicine remains to be established, promising advances have included their ability to stratify high risk individuals and targeted screening intervention...
2 weeks ago
Institution: Department of Informatics, Faculty of Mathematics and Natural Sciences, South-West University, 2700 Blagoevgrad, Bulgaria
Email:
Radoslava Kraleva
Radoslava Kraleva
Institution: Department of Informatics, Faculty of Mathematics and Natural Sciences, South-West University, 2700 Blagoevgrad, Bulgaria
Email:
This research is focused on evolutionary algorithms, with genetic and memetic algorithms discussed in more detail. A graph theory problem related to finding a minimal Hamiltonian cycle in a complete undirected graph (Travelling Salesman Problem—TSP) is considered. The implementations of two approximate algorithms for solving this problem, genetic and memetic, are presented. The main obje...
1 month ago
Institution: Department of Analytical & Applied Economics, Utkal University, Bhubaneswar 751004, India
Email:
Himanshu Sekhar Rout,
Himanshu Sekhar Rout
Institution: Department of Analytical & Applied Economics, Utkal University, Bhubaneswar 751004, India
Email:
Mihajlo Jakovljevic
Mihajlo Jakovljevic
Institution: Institute of Advanced Manufacturing Technologies, Peter the Great St. Petersburg Polytechnic University, 195251 St. Petersburg, Russia
Email:
Despite economic progress, government efforts, and increased healthcare investments, health deprivation continues to persist in the countries of Brazil, Russia, India, China, and South Africa (BRICS). Hence, addressing the growing demand for health financing in a sustainable way and adopting unique approaches to healthcare provision is essential. This paper aims to review publications on the exist...
1 month ago
Institution: Department of Veterinary Sciences, University of Turin, Largo Paolo Braccini 2, 10095 Grugliasco, Italy
Email:
Claudia Castagna,
Claudia Castagna
Institution: Department of Veterinary Sciences, University of Turin, Largo Paolo Braccini 2, 10095 Grugliasco, Italy
Email:
Adalberto Merighi
Adalberto Merighi
Institution: Department of Veterinary Sciences, University of Turin, Largo Paolo Braccini 2, 10095 Grugliasco, Italy
Email:
Epigenetic changes are changes in gene expression that do not involve alterations to the DNA sequence. These changes lead to establishing a so-called epigenetic code that dictates which and when genes are activated, thus orchestrating gene regulation and playing a central role in development, health, and disease. The brain, being mostly formed by cells that do not undergo a renewal process through...
1 month ago
With the rapid development of biotechnology, gene sequencing methods are gradually improved. The structure of gene sequences is also more complex. However, the traditional sequence alignment method is difficult to deal with the complex gene sequence alignment work. In order to improve the efficiency of gene sequence analysis, D2 series method of k-mer statistics is selected to build the model of g...
2 months ago
It’s been 10 years now from the debut of clustered regularly interspaced short palindromic repeats-associated protein 9 (CRISPR/Cas9) era in which gene engineering has never been so accessible, precise and efficient. This technology, like a refined surgical procedure, has offered the ability of removing different types of disease causing mutations and restoring key proteins activity with ease of...
2 months ago
Background
Genetic counselling (GC) is an integral component in the care of individuals at risk for hereditary cancer predisposition syndromes (CPS). In many jurisdictions, access to timely counselling and testing is limited by financial constraints, by the shortage of genetics professionals and by labor-intensive traditional models of individual pre and post-test counselling. There is a need for...
2 months ago