The coronavirus disease 2019 (COVID-19) pandemic has affected vulnerable households’ livelihoods in developing countries. Using high-frequency phone survey data from the World Bank, we assess rural Indian households’ vulnerability and poverty status during the pandemic. Results reveal that over three-fifths of Indian rural households are vulnerable to poverty in the context of COVID-19, despit...
1 month ago
Institution: The Hormel Institute, University of Minnesota, Austin, MN 55912, USA
Email:
Michael E. Grossmann,
Michael E. Grossmann
Institution: The Hormel Institute, University of Minnesota, Austin, MN 55912, USA
Email:
Sarah A. Ewing,
Sarah A. Ewing
Institution: The Hormel Institute, University of Minnesota, Austin, MN 55912, USA
Email:
Olga P. Rogozina,
Olga P. Rogozina
Institution: The Hormel Institute, University of Minnesota, Austin, MN 55912, USA
Email:
Amitabha Ray,
Amitabha Ray
Institution: The Hormel Institute, University of Minnesota, Austin, MN 55912, USA
Email:
Katai J. Nkhata,
Katai J. Nkhata
Institution: The Hormel Institute, University of Minnesota, Austin, MN 55912, USA
Email:
D. Joshua Liao,
D. Joshua Liao
Institution: The Hormel Institute, University of Minnesota, Austin, MN 55912, USA
Email:
Joseph P. Grande,
Joseph P. Grande
Institution: Department of Pathology and Laboratory Medicine, Mayo Clinic, Rochester, MN 55905, USA
Email:
Margot P. Cleary
Margot P. Cleary
Institution: The Hormel Institute, University of Minnesota, Austin, MN 55912, USA
Email:
To clarify effects of diet and body weight on prostate cancer development, three studies were undertaken using the TRAMP mouse model of this disease. In the first experiment, obesity was induced by injection of gold thioglucose (GTG). Age of prostate tumor detection (~33 wk) and death (~43 wk) was not significantly different among the groups. In the second study, TRAMP-C2 cells were injected i...
1 month ago
Hereditary non-polyposis colorectal cancer (HNPCC) is an inherited disorder characterized by an increased risk of developing colorectal cancer before age 50. HNPCC is predominantly caused by genetic mutations in MLH1 and MSH2, which are involved in DNA mismatch repair. Current standard practice is to perform prophylactic colectomy, resulting in debilitating aftereffects for life. Though the geneti...
1 month ago
The purpose of this paper is to provide a review of hereditary non-polyposis colorectal cancer. This paper covers the causes, epidemiology, pathophysiology, histology, diagnosis, and treatment for the disease....
1 month ago
Background
Hereditary papillary renal cell carcinoma (HPRCC) is a rare autosomal dominant disease characterized by the development of multiple and bilateral papillary type I renal cell carcinomas (RCC) and papillary adenomas caused by activating mutations in the MET proto-oncogene. Classically, distinctive histological features of RCC are described according to the familial renal cell carcinoma s...
1 month ago
In hereditary leiomyomatosis and renal cell carcinoma syndrome, fumarate hydratase–deficient renal cell carcinomas typically present as aggressive, unilateral, often cystic masses with heterogeneous enhancement. These tumors can metastasize early, making appropriate imaging and staging critical for diagnosis and management.
Teaching point: When a renal lesion suspected of RCC is identified in...
1 month ago
Hereditary leiomyomatosis and renal cell carcinoma (HLRCC) syndrome is believed to result from an autosomal dominant mutation in the fumarate hydratase (FH) gene on chromosome 1. It is characterized by leiomyomas, mainly uterine or cutaneous, and renal cell carcinoma (RCC). The most common type of RCC associated with HLRCC is type II papillary RCC although other types are seen. Of note, chromophob...
1 month ago
Hereditary leiomyomatosis and renal cell cancer syndrome (HLRCC) associated renal cell carcinoma (RCC) is an aggressive form of type 2 papillary RCC caused by deficiency of the fumarate hydratase gene. For patients with metastatic disease, no standard treatment has been established with dismal prognosis. We report a case of metastatic HLRCC-associated RCC in a 65-year-old Japanese male whose clini...
1 month ago
Institution: E.J. Whitten Prostate Cancer Research Centre, Epworth Healthcare, Melbourne, VIC 3005, Australia
Email:
Thomas P. Cundy,
Thomas P. Cundy
Institution: Discipline of Surgery, University of Adelaide, Adelaide, SA 5005, Australia
Email:
Dixon T. S. Woon,
Dixon T. S. Woon
Institution: E.J. Whitten Prostate Cancer Research Centre, Epworth Healthcare, Melbourne, VIC 3005, Australia
Email:
Nathan Lawrentschuk
Nathan Lawrentschuk
Institution: E.J. Whitten Prostate Cancer Research Centre, Epworth Healthcare, Melbourne, VIC 3005, Australia
Email:
Early detection of metastatic prostate cancer (mPCa) is crucial. Whilst the prostate-specific membrane antigen (PSMA) PET scan has high diagnostic accuracy, it suffers from inter-reader variability, and the time-consuming reporting process. This systematic review was registered on PROSPERO (ID CRD42023456044) and aims to evaluate AI’s ability to enhance reporting, diagnostics, and predic...
1 month ago