Priscilla Namaganda,
Priscilla Namaganda
Institution:
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Jane Nakibuuka,
Jane Nakibuuka
Institution:
Email:
Mark Kaddumukasa,
Mark Kaddumukasa
Institution:
Email:
Elly Katabira
Elly Katabira
Institution:
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Abstract
Background
Stroke is the second leading cause of death above the age of 60 years, and the fifth leading cause in people aged 15 to 59 years old as reported by the World Health Organization global burden of diseases. Stroke in the young is particularly tragic because of the potential to ...
4 months ago
Diana W Shineman,
Diana W Shineman
Institution:
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Howard M Fillit
Howard M Fillit
Institution:
Email:
The article "Meeting the unique challenges of drug discovery for neurodegenerative diseases" discusses the complexities and opportunities in developing therapeutics for conditions such as Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, and multiple sclerosis. The authors emphasize the need for a multidisciplinary approach, integrating academic rese...
4 months ago
Karen L Steinmetz,
Karen L Steinmetz
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Edward G Spack
Edward G Spack
Institution:
Email:
The article "The basics of preclinical drug development for neurodegenerative disease indications" provides an overview of the essential steps involved in transitioning a drug candidate from laboratory discovery to human clinical trials. It emphasizes the importance of preclinical studies in identifying lead candidates, developing scalable production methods, selecting optimal formulations, and...
4 months ago
William A Banks
William A Banks
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The article "Characteristics of compounds that cross the blood-brain barrier" discusses the mechanisms by which substances traverse the blood-brain barrier (BBB), focusing on transmembrane diffusion and transporters. It highlights that transmembrane diffusion is non-saturable and depends on the physicochemical properties of the substance. Additionally, the article notes that brain-to-blood effl...
4 months ago
Ahmet S. Ozcan,
Ahmet S. Ozcan
Institution:
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Mehmet S. Ozcan
Mehmet S. Ozcan
Institution:
Email:
This article investigates the formation and elimination of dendritic spines—small protrusions on neurons that facilitate synaptic connections.
The authors employ a mathematical model based on the Ricker population model, commonly used in ecology to describe population dynamics. This model incorporates "immigration" through filopodia-type transient spines, suggesting that these transient s...
5 months ago
Hey-Kyoung Lee
Hey-Kyoung Lee
Institution:
Email:
Sensory loss leads to widespread adaptation of neural circuits to mediate cross-modal plasticity, which allows the organism to better utilize the remaining senses to guide behavior. While cross-modal interactions are often thought to engage multisensory areas, cross-modal plasticity is often prominently observed at the level of the primary sensory cortices. One dramatic example is from functional ...
5 months ago
Dustin N. White,
Dustin N. White
Institution:
Email:
Michael H. B. Stowell
Michael H. B. Stowell
Institution:
Email:
Synaptic vesicle release is regulated by upwards of 30 proteins at the fusion complex alone, but disruptions in any one of these components can have devastating consequences for neuronal communication. Aberrant molecular responses to calcium signaling at the pre-synaptic terminal dramatically affect vesicle trafficking, docking, fusion, and release. At the organismal level, this is reflected in di...
5 months ago
Chengji Piao,
Chengji Piao
Institution:
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Stephan J. Sigrist
Stephan J. Sigrist
Institution:
Email:
The so-called active zones at pre-synaptic terminals are the ultimate filtering devices, which couple between action potential frequency and shape, and the information transferred to the post-synaptic neurons, finally tuning behaviors. Within active zones, the release of the synaptic vesicle operates from specialized “release sites.” The (M)Unc13 class of proteins is meant to define release si...
5 months ago
Simon Andrew Vann Jones,
Simon Andrew Vann Jones
Institution:
Email:
Allison O’Kelly
Allison O’Kelly
Institution:
Email:
Currently, there are no disease-modifying treatments for Alzheimer’s disease (AD) or any
other dementia subtype. The renaissance in psychedelic research in recent years, in
particular studies involving psilocybin and lysergic acid diethylamide (LSD), coupled with
anecdotal reports of cognitive benefits from micro-dosing, suggests that they may have a
therapeutic role in a range of psy...
5 months ago
Christian G. Specht
Christian G. Specht
Institution:
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The function of synapses depends on spatially and temporally controlled molecular interactions between synaptic components that can be described in terms of copy numbers, binding affinities, and diffusion properties. To understand the functional role of a given synaptic protein, it is therefore crucial to quantitatively characterise its biophysical behaviour in its native cellular environment. Sin...
5 months ago