Genetics Research Articles

Biomedical

Combining Genetic Algorithm with Local Search Method in Solving Optimization Problems

This research focuses on evolutionary algorithms, particularly genetic and memetic algorithms. The study examines a graph theory problem related to finding a minimal Hamiltonian cycle in a complete undirected graph (Travelling Salesman Problem-TSP). The paper presents implementations of two approximate algorithms for solving this problem: genetic and memetic. The main objective is to determine the...
1 month ago

Biomedical

Generalisation of genomic findings and applications of polygenic risk scores

Polygenic Risk Scores (PRS) (also known as polygenic scores, genetic risk scores or polygenic indexes) capture genetic contributions of a multitude of markers that characterise complex traits. Although their likely application to precision medicine remains to be established, promising advances have included their ability to stratify high risk individuals and targeted screening intervention...
2 months ago

Biomedical

Combining Genetic Algorithm with Local Search Method in Solving Optimization Problems

This research is focused on evolutionary algorithms, with genetic and memetic algorithms discussed in more detail. A graph theory problem related to finding a minimal Hamiltonian cycle in a complete undirected graph (Travelling Salesman Problem—TSP) is considered. The implementations of two approximate algorithms for solving this problem, genetic and memetic, are presented. The main obje...
3 months ago

Biomedical

Dynamics of Health Financing among the BRICS: A Literature Review

Despite economic progress, government efforts, and increased healthcare investments, health deprivation continues to persist in the countries of Brazil, Russia, India, China, and South Africa (BRICS). Hence, addressing the growing demand for health financing in a sustainable way and adopting unique approaches to healthcare provision is essential. This paper aims to review publications on the exist...
3 months ago

Biomedical

An Overview of the Epigenetic Modifications in the Brain under Normal and Pathological Conditions

Epigenetic changes are changes in gene expression that do not involve alterations to the DNA sequence. These changes lead to establishing a so-called epigenetic code that dictates which and when genes are activated, thus orchestrating gene regulation and playing a central role in development, health, and disease. The brain, being mostly formed by cells that do not undergo a renewal process through...
3 months ago

Biomedical

Gene sequence analysis model construction based on k-mer statistics

With the rapid development of biotechnology, gene sequencing methods are gradually improved. The structure of gene sequences is also more complex. However, the traditional sequence alignment method is difficult to deal with the complex gene sequence alignment work. In order to improve the efficiency of gene sequence analysis, D2 series method of k-mer statistics is selected to build the model of g...
3 months ago

Biomedical

What did CRISPR-Cas9 accomplish in its first 10 years?

It’s been 10 years now from the debut of clustered regularly interspaced short palindromic repeats-associated protein 9 (CRISPR/Cas9) era in which gene engineering has never been so accessible, precise and efficient. This technology, like a refined surgical procedure, has offered the ability of removing different types of disease causing mutations and restoring key proteins activity with ease of...
3 months ago

Biomedical

Hereditary non-polyposis colorectal cancer (HNPCC) and its genetic basis

Summary

Introduction

Hereditary non-polyposis colorectal cancer (HNPCC), also known as Lynch syndrome, is an inherited condition that increases the risk of developing colorectal and other types of cancer. It is caused by mutations in one of several genes involved in DNA repair, ...
4 months ago

Biomedical

Group plus “mini” individual pre-test genetic counselling sessions for hereditary cancer shorten provider time and improve patient satisfaction

Background Genetic counselling (GC) is an integral component in the care of individuals at risk for hereditary cancer predisposition syndromes (CPS). In many jurisdictions, access to timely counselling and testing is limited by financial constraints, by the shortage of genetics professionals and by labor-intensive traditional models of individual pre and post-test counselling. There is a need for...
4 months ago

Biomedical

Meeting abstracts from the Annual Conference “Clinical Genetics of Cancer 2022”

Desmoid Tumors and Familial Adenomatous Polyposis:
CTNNB1 mutations are linked to sporadic desmoid disease. Although APC mutations are mainly associated with inherited FAP, some sporadic desmoid cases may involve APC mutations that correlate with tumor development.
Germline Genetic Basis of Cancer:
Large-scale se...
4 months ago

Genetics

Summary

Introduction

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