Biomedical
Peer Reviewed
mtDNA deletions are mutations where segments of the mitochondrial genome are lost, leading to dysfunctional mitochondria. These deletions can accumulate over time, potentially impairing cellular energy production and contributing to aging. :contentReference[oaicite:1]{index=1}
Accumulation of mtDNA deletions over time can lead to mitochondrial dysfunction, which is a hallmark of aging. This dysfunction may contribute to age-related diseases and the overall aging process by impairing cellular energy metabolism. :contentReference[oaicite:2]{index=2}
Quantifying mtDNA deletions is complex due to their heterogeneous nature and the difficulty in detecting low-abundance mutations. Additionally, the diverse results across different models highlight the need for standardized methodologies to assess the impact of mtDNA deletions on aging. :contentReference[oaicite:3]{index=3}
Show by month | Manuscript | Video Summary |
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2025 April | 2 | 2 |
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2025 January | 47 | 47 |
2024 December | 68 | 68 |
2024 November | 47 | 47 |
2024 October | 17 | 17 |
Total | 288 | 288 |
Show by month | Manuscript | Video Summary |
---|---|---|
2025 April | 2 | 2 |
2025 March | 59 | 59 |
2025 February | 48 | 48 |
2025 January | 47 | 47 |
2024 December | 68 | 68 |
2024 November | 47 | 47 |
2024 October | 17 | 17 |
Total | 288 | 288 |