Key Questions
What are Polygenic Risk Scores?
Polygenic Risk Scores (PRS) capture genetic contributions of multiple markers that characterize complex traits. They can help predict disease risk at early stages.
How can PRS be applied in healthcare?
PRS can be used for disease prevention, improving clinical management, drug development, population risk stratification, and targeted screening interventions.
What are the challenges in implementing PRS?
Challenges include limited diversity in training data, difficulty in choosing appropriate PRS for testing, and translating PRS into actionable benefits for individuals.
How can PRS be applied at scale?
Applying PRS at scale requires collecting diverse data through biobanks, developing clinical trials using PRS, and creating public/private partnerships with genetic testing companies.
What ethical considerations are there for PRS implementation?
Ethical considerations include patient privacy, informed consent, and potential genetic discrimination. Healthcare providers need training to properly communicate PRS-based genetic risk.
