Biomedical
Cell autocloning as a pathway to their real rejuvenation
Abstract
The article gives a brief description of geroprotection and rejuvenation methods known to date, presenting their main mechanisms and limitations. To overcome the main limitations of the process of rejuvenation, it is possible to use a process called “cell autocloning.” The principle of the proposed method of rejuvenation is as follows: a periodic process of autocloning of the cell nucleus is initiated in the cellular genome with the formation of one unstable daughter copy and its subsequent self-elimination. In this case, the process of cell division stops in the phase of nuclei divergence without subsequent physical separation of the cell itself. This is especially important for postmitotic cells, where the looping of the “unidirectional” line of the ontogenesis program into a “ring” will mean their transition into renewable cells. The prototype for autocloning mechanisms could be the already known ways in which cells adapt to the increasing amount of their damage over time. These are polyploidy and asymmetric cell division, relying on which it is possible to obtain a renewable process of cell nuclei division, when only the original nucleus remains as a result of division. Although this is not a simple task, there are possible pathways to its solution using approaches that can suggest modern knowledge from the field of molecular and cell biology and genetics. The realization of such a goal will require a lot of work, but the expected result justifies it.
Key Questions and Answers
What is cell autocloning, and how does it work?
Cell autocloning involves a process where cells replicate and rejuvenate themselves, potentially reversing aging and restoring damaged tissues.
How does cell autocloning help in rejuvenation?
It promotes the regeneration of youthful, functional cells by facilitating their self-replication, thereby rejuvenating tissues.
Can cell autocloning reverse the aging process?
Cell autocloning could slow or partially reverse aging by regenerating aged cells, offering potential in anti-aging therapies.
What are the potential benefits of cell autocloning in medicine?
It could be used for regenerative medicine, improving tissue repair and combating degenerative diseases.
How does cell autocloning affect tissue regeneration?
Autocloning accelerates tissue regeneration by rejuvenating aging or damaged cells, potentially healing tissues more effectively.
What are the challenges in applying cell autocloning in human therapies?
Challenges include ensuring safety, controlling the cloning process, and preventing unintended side effects.
How does cell autocloning compare to other rejuvenation techniques?
Compared to other methods, cell autocloning offers a direct way to rejuvenate cells by replicating them, potentially more effective in long-term tissue repair.
