Diana W Shineman,
Diana W Shineman
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Howard M Fillit
Howard M Fillit
Institution:
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...
1 month ago
Karen L Steinmetz,
Karen L Steinmetz
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Edward G Spack
Edward G Spack
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...
1 month ago
William A Banks
William A Banks
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...
1 month ago
Ahmet S. Ozcan,
Ahmet S. Ozcan
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Mehmet S. Ozcan
Mehmet S. Ozcan
Institution:
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...
1 month ago
Hey-Kyoung Lee
Hey-Kyoung Lee
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Sensory loss leads to widespread adaptation of neural circuits to mediate cross-modal plasticity, which allows the organism to better utilize the remaining senses to guide behavior. While cross-modal interactions are often thought to engage multisensory areas, cross-modal plasticity is often prominently observed at the level of the primary sensory cortices. One dramatic example is from functional ...
1 month ago
Dustin N. White,
Dustin N. White
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Michael H. B. Stowell
Michael H. B. Stowell
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Synaptic vesicle release is regulated by upwards of 30 proteins at the fusion complex alone, but disruptions in any one of these components can have devastating consequences for neuronal communication. Aberrant molecular responses to calcium signaling at the pre-synaptic terminal dramatically affect vesicle trafficking, docking, fusion, and release. At the organismal level, this is reflected in di...
1 month ago
Chengji Piao,
Chengji Piao
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Stephan J. Sigrist
Stephan J. Sigrist
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The so-called active zones at pre-synaptic terminals are the ultimate filtering devices, which couple between action potential frequency and shape, and the information transferred to the post-synaptic neurons, finally tuning behaviors. Within active zones, the release of the synaptic vesicle operates from specialized “release sites.” The (M)Unc13 class of proteins is meant to define release si...
1 month ago
Simon Andrew Vann Jones,
Simon Andrew Vann Jones
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Allison O’Kelly
Allison O’Kelly
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...
1 month ago
Christian G. Specht
Christian G. Specht
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The function of synapses depends on spatially and temporally controlled molecular interactions between synaptic components that can be described in terms of copy numbers, binding affinities, and diffusion properties. To understand the functional role of a given synaptic protein, it is therefore crucial to quantitatively characterise its biophysical behaviour in its native cellular environment. Sin...
1 month ago
Hansen Wang
Hansen Wang
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Microglia are resident immune cells in the central nervous system and play critical roles in brain immunity, development, and homeostasis. The pathology of Alzheimer’s disease (AD) triggers activation of microglia. Microglia express many AD risk genes, suggesting that their response to AD pathology can affect disease progression. Microglia have long been considered a homogenous cell population. ...
1 month ago