Biochemistry

Biomedical

Unexpected abnormal coagulation test results in a 2-year-old child


Rejection of the sample with repeated blood withdrawal is always an unwanted consequence of sample nonconformity and preanalytical errors, especially in the most vulnerable population – children. Here is presented a case with unexpected abnormal coagulation test results in a 2-yearold child with no previously documented coagulation disorder. Child is planned for tympanostomy tubes removal unde...
2 months ago

Biomedical

Affordable Biologics for All


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2 months ago

Biomedical

Diagnostic role of urine human epididymis protein 4 in ovarian cancer


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2 months ago

Biomedical

Clinical importance of laboratory biomarkers in liver fibrosis


Hepatic cirrhosis is a major health problem across the world, causing high morbidity and mortality. This disease has many etiologies, yet the result of chronic hepatic injury is hepatic fibrosis causing cirrhosis and hepatocellular carcinoma, as the liver’s architecture is progressively destroyed. While liver biopsy is currently the gold standard for fibrosis staging, it has significant disadvan...
2 months ago

Biomedical

A sudden creatinine increase: A case report


Creatinine and estimated glomerular filtration rate (eGFR) are first-line laboratory parameters in the diagnosis of various renal diseases. In recent decades, cystatin C (cysC) has furthered the laboratory repertoire regarding renal status assessment and has been implemented in many clinical guidelines. Accordingly, with the establishment of cysC as a renal routine biomarker, further opportunities...
2 months ago

Biomedical

Underfilled blood tube containing EDTA


Introduction Blood samples having inappropriate volume are a substantial part of preanalytical errors. Inadequate sample volume for glycated haemoglobin (HbA1c) test may be a common problem of patients with diabetes mellitus having vascular changes. In this study, we compared HbA1c concentrations of underfilled and appropriately filled blood collection tubes. Materials and methods To compare Hb...
2 months ago

Biomedical

Defining laboratory medicine, or squaring the circle?


In the August 2020 issue of Clinical Chemistry and Laboratory Medicine, Giuseppe Lippi and Mario Plebani proposed a definition of laboratory medicine, which ends with this sentence: “The results of these measurements are translated into actionable information for improving the care and/or maintaining the wellness of both a single individual and an entire population”. Nevertheless, the selfishn...
2 months ago

Biomedical

Complete blood count alterations in COVID-19 patients


Coronavirus disease 2019 (COVID-19) pandemic represents a scientific and social crisis. One of the main unmet needs for coronavirus disease 2019 is its unpredictable clinical course, which can rapidly change in an irreversible outcome. COVID-19 patients can be classified into mild, moderate, and severe. Several haematological parameters, such as platelets, white blood cell total count, lymphocytes...
2 months ago

Biomedical

Extracellular vesicles and glycans


Highlights • Biological fluids contain nano-sized particles called extracellular vesicles • Extracellular vesicles properties reflect the physiological and pathological state of the parent cells • Extracellular vesicles as analytes are suitable for use in liquid biopsy-based real-time diagnostics • Glycans, complex oligosaccharides, are distinct components of extracellular vesicles mem...
2 months ago

Biomedical

Glucose inhibitor tubes in Croatian laboratories: are we doing well?


Introduction Reliable and accurate measurement of blood glucose concentration is of crucial importance for making clinical decisions in diagnosis diabetes, gestational diabetes and impaired fasting glucose tolerance. Materials and methods Survey was performed in form of questionnaire. Questionnaire was sent to all Croatian laboratories (N = 204) in electronic form using SurveyMonkey cloud-bas...
2 months ago

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