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Sambasivarao Kotha,
Sambasivarao Kotha
Institution: Department of Chemistry, Indian Institute of Technology, Bombay 400076, India
Email:
Subba Rao Cheekatla
Subba Rao Cheekatla
Institution: Department of Chemistry, Indian Institute of Technology, Bombay 400076, India
Email:
Herein, we report a bisoxazole derivative as well as a bromo-substituted oxazole derivatives via a simple approach. The synthesis begins with an inexpensive and readily available starting material, such as 2,5-dimethoxybenzaldehyde, hydroquinone, and p-toluenesulfonylmethyl isocyanide (TosMIC). This approach relies on the Van Leusen oxazole method and electrophilic aromatic bromination. Th...
4 months ago
Ridho Asra,
Ridho Asra
Institution: School of Pharmacy, Institute of Clinical Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK
Email:
Aigul Erbosynovna Malmakova,
Aigul Erbosynovna Malmakova
Institution: School of Pharmacy, Institute of Clinical Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK
Email:
Alan M. Jones
Alan M. Jones
Institution: School of Pharmacy, Institute of Clinical Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK
Email:
Abstract
The tractable preparation of Phase I drug metabolites is a critical step to understand the first-pass behaviour of novel chemical entities (NCEs) in drug discovery. In this study, we have developed a structure–electroactivity relationship (SeAR)-informed electrochemical reaction of the parent 2-chlorophenothiazine and the ...
4 months ago
Arielle Woznica
Arielle Woznica
Institution:
Email:
Summary
This study examines the relationship between carbon emissions and low-carbon innovation in firms using panel data from Chinese A-share listed companies from 2010 to 2019. The key findings include:
- Carbon emissions promote low-carbon innovation in firms
- This effect is mediated by carbon emissions reduction pressure...
4 months ago
Krystal M. Cid-Seara,
Krystal M. Cid-Seara
Institution: Departamento de Química Inorgánica, Universidade de Vigo, Campus Universitario, 36310 Vigo, Spain
Email:
Raquel Pereira-Cameselle,
Raquel Pereira-Cameselle
Institution: Departamento de Química Orgánica, Universidade de Vigo, Campus Universitario, 36310 Vigo, Spain
Email:
Sandra Bolaño,
Sandra Bolaño
Institution: Departamento de Química Inorgánica, Universidade de Vigo, Campus Universitario, 36310 Vigo, Spain
Email:
Maria Talavera
Maria Talavera
Institution: Departamento de Química Inorgánica, Universidade de Vigo, Campus Universitario, 36310 Vigo, Spain
Email:
Organic amines are important compounds present in a wide variety of products, which makes the development of new systems for their detection an interesting field of study. New organometallic complexes of group 9 [MCp*X(2′-R-2-py-SBF)] (M = Ir, Rh; R = H, X = Cl (6), R = H, X = OAc (7), R = CHO, X = Cl (8)), and [IrCp*Cl(2′, 7-diCHO-2-py-SBF)] (9) (Cp* pentamethylcyclopentadienyl, SBF =...
4 months ago
Omar Ali Shaban Al-Awad,
Omar Ali Shaban Al-Awad
Institution: School of Agriculture and Environment, University of Western Australia, 35 Stirling Highway, Perth, WA 6009, Australia
Email:
Kit Stasia Prendergast,
Kit Stasia Prendergast
Institution: School of Molecular and Life Sciences, Curtin University, Kent Street, Bentley, Perth, WA 6102, Australia
Email:
Alan Robson,
Alan Robson
Institution: School of Agriculture and Environment, University of Western Australia, 35 Stirling Highway, Perth, WA 6009, Australia
Email:
Zed Rengel
Zed Rengel
Institution: School of Agriculture and Environment, University of Western Australia, 35 Stirling Highway, Perth, WA 6009, Australia
Email:
Soil ammonium toxicity can decrease plant growth, and many crop species have low resistance to ammonium, including canola, an economically important crop. Different genotypes may differ in their resistance to ammonium toxicity, and therefore determining if there are genotypes that exhibit variation in their ability to tolerate soil ammonium is a research priority. Here, we evaluate how soi...
5 months ago
Elain Fu,
Elain Fu
Institution: School of Chemical, Biological and Environmental Engineering, Oregon State University, Corvallis, OR 97331, USA
Email:
Khadijeh Khederlou,
Khadijeh Khederlou
Institution: School of Chemical, Biological and Environmental Engineering, Oregon State University, Corvallis, OR 97331, USA
Email:
Noël Lefevre,
Noël Lefevre
Institution: School of Chemical, Biological and Environmental Engineering, Oregon State University, Corvallis, OR 97331, USA
Email:
Stephen A. Ramsey,
Stephen A. Ramsey
Institution: School of Electrical Engineering and Computer Science, Oregon State University, Corvallis, OR 97331, USA
Email:
Matthew L. Johnston,
Matthew L. Johnston
Institution: School of Electrical Engineering and Computer Science, Oregon State University, Corvallis, OR 97331, USA
Email:
Lael Wentland
Lael Wentland
Institution: School of Chemical, Biological and Environmental Engineering, Oregon State University, Corvallis, OR 97331, USA
Email:
Electrochemical detection, with its advantages of being rapid, multi-time point, compatible with cost-effective fabrication methods, and having the potential for miniaturization and portability, has great promise for point-of-care drug monitoring. However, a continuing challenge concerns the robust and sensitive electrochemical detection of pharmaceutical analytes from biological fluids. T...
5 months ago
Mònica Campàs,
Mònica Campàs
Institution: IRTA, Marine and Continental Waters (AMiC) Programme, Ctra. Poble Nou del Delta, km. 5.5, 43540 La Ràpita, Spain
Email:
Jaume Reverté,
Jaume Reverté
Institution: IRTA, Marine and Continental Waters (AMiC) Programme, Ctra. Poble Nou del Delta, km. 5.5, 43540 La Ràpita, Spain
Email:
Àngels Tudó,
Àngels Tudó
Institution: Department of Basic Medical Sciences, Universitat Rovira i Virgili, C/Sant Llorenç 21, 43201 Reus, Spain
Email:
Mounira Alkassar,
Mounira Alkassar
Institution: IRTA, Marine and Continental Waters (AMiC) Programme, Ctra. Poble Nou del Delta, km. 5.5, 43540 La Ràpita, Spain
Email:
Jorge Diogène,
Jorge Diogène
Institution: IRTA, Marine and Continental Waters (AMiC) Programme, Ctra. Poble Nou del Delta, km. 5.5, 43540 La Ràpita, Spain
Email:
Francesc X. Sureda
Francesc X. Sureda
Institution: Department of Basic Medical Sciences, Universitat Rovira i Virgili, C/Sant Llorenç 21, 43201 Reus, Spain
Email:
Tetrodotoxin (TTX) is a marine toxin responsible for many intoxications around the world. Its presence in some pufferfish species and, as recently reported, in shellfish, poses a serious health concern. Although TTX is not routinely monitored, there is a need for fast, sensitive, reliable, and simple methods for its detection and quantification. In this work, we describe the use of an auto...
5 months ago
James P. C. Coverdale,
James P. C. Coverdale
Institution: School of Pharmacy, Institute of Clinical Sciences, University of Birmingham, Edgbaston B15 2TT, UK
Email:
Sirilata Polepalli,
Sirilata Polepalli
Institution: Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK
Email:
Marco A. Z. Arruda,
Marco A. Z. Arruda
Institution: Institute of Chemistry, Department of Analytical Chemistry, Universidade Estadual de Campinas, Campinas 13083-970, Brazil
Email:
Ana B. Santos da Silva,
Ana B. Santos da Silva
Institution: Institute of Chemistry, Department of Analytical Chemistry, Universidade Estadual de Campinas, Campinas 13083-970, Brazil
Email:
Alan J. Stewart,
Alan J. Stewart
Institution: School of Medicine, University of St. Andrews, St Andrews KY16 9TF, UK
Email:
Claudia A. Blindauer
Claudia A. Blindauer
Institution: Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK
Email:
Interactions between proteins and metal ions and their complexes are important in many areas of the life sciences, including physiology, medicine, and toxicology. Despite the involvement of essential elements in all major processes necessary for sustaining life, metalloproteomes remain ill-defined. This is not only owing to the complexity of metalloproteomes, but also to the non-covalent c...
5 months ago
Zhongbo Liu,
Zhongbo Liu
Institution: Department of Urology, University of California Irvine, Orange, CA 92868, USA
Email:
Liankun Song,
Liankun Song
Institution: Department of Urology, University of California Irvine, Orange, CA 92868, USA
Email:
Jun Xie,
Jun Xie
Institution: Department of Urology, University of California Irvine, Orange, CA 92868, USA
Email:
Xue-Ru Wu,
Xue-Ru Wu
Institution: Department of Urology, NYU School of Medicine, New York, NY 10016, USA
Email:
Greg E. Gin,
Greg E. Gin
Institution: Department of Urology, University of California Irvine, Orange, CA 92868, USA
Email:
Beverly Wang,
Beverly Wang
Institution: Department of Pathology and Laboratory Medicine, University of California, Irvine, Orange, CA 92868, USA
Email:
Edward Uchio,
Edward Uchio
Institution: Department of Urology, University of California Irvine, Orange, CA 92868, USA
Email:
Xiaolin Zi
Xiaolin Zi
Institution: Department of Urology, University of California Irvine, Orange, CA 92868, USA
Email:
UPII-mutant Ha-ras transgenic mice develop urothelial hyperplasia and low-grade papillary carcinoma, which mimics human non-muscle invasive bladder cancer (NMIBC). We investigated the effects and mechanisms of kawain, a main kavalactone in the kava plant, on oncogenic Ha-ras-driven urothelial carcinoma in these mice. The mice were fed at six weeks of age with vehicle control or kawain (6 g...
5 months ago
Lev Salnikov
Lev Salnikov
Institution:
Email:
The article gives a brief description of geroprotection and rejuvenation methods known to date, presenting their main mechanisms and limitations. To overcome the main limitations of the process of rejuvenation, it is possible to use a process called “cell autocloning.” The principle of the proposed method of rejuvenation is as follows: a periodic process of autocloning of the cell nucleus is i...
6 months ago