Biochemistry

Biomedical

Preanalytical, analytical and postanalytical considerations in circulating microRNAs measurement

Highlights • Methods used for miRNAs expression profiling are quantitative reverse transcription polymerase chain reaction, microarrays, next generation sequencing and droplet digital PCR • To obtain reproducible and accurate miRNAs expression profiling detection, it is crucial to strictly standardize the entire process, starting from choosing the specimen type until the normalization strate...
2 months ago

Biomedical

Antiphospholipid antibodies in patients with antiphospholipid syndrome

Highlights • Antiphospholipid syndrome is a rare systemic autoimmune disease characterized by recurrent pregnancy morbidity or thrombosis in combination with the persistent presence of antiphospholipid antibodies in plasma/serum • Specialists in laboratory medicine should take responsibility for the entire analytical process, so that possible interferences are minimized, and physicians obtai...
2 months ago

Biomedical

Transcription factors organize into functional groups on the linear genome and in 3D chromatin

Transcription factors (TFs) and their binding sites have evolved to interact cooperatively or competitively with each other. Here we examine in detail, across multiple cell lines, such cooperation or competition among TFs both in sequential and spatial proximity (using chromatin conformation capture assays) on one hand, and based on both in vivo binding as well as TF binding motifs on the other. W...
2 years ago

Biomedical

Predicting the Oxidation States of Mn ions in the Oxygen Evolving Complex of Photosystem II Using Supervised and Unsupervised Machine Learning

Serial Femtosecond Crystallography at the X-ray Free Electron Laser (XFEL) sources enabled the imaging of the catalytic intermediates of the oxygen evolution reaction of Photosystem II. However, due to the incoherent transition of the S-states, the resolved structures are a convolution from different catalytic states. Here, we train Decision Tree Classifier and K-mean clustering models on Mn...
2 years ago

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Biochemistry

Preanalytical, analytical and postanalytical considerations in circulating microRNAs measurement

Antiphospholipid antibodies in patients with antiphospholipid syndrome

Transcription factors organize into functional groups on the linear genome and in 3D chromatin

Predicting the Oxidation States of Mn ions in the Oxygen Evolving Complex of Photosystem II Using Supervised and Unsupervised Machine Learning

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