Biochemistry

Extracellular vesicles and glycans

Highlights • Biological fluids contain nano-sized particles called extracellular vesicles • Extracellular vesicles properties reflect the physiological and pathological state of the parent cells • Extracellular vesicles as analytes are suitable for use in liquid biopsy-based real-time diagn...
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1 week ago

Glucose inhibitor tubes in Croatian laboratories: are we doing well?

Introduction Reliable and accurate measurement of blood glucose concentration is of crucial importance for making clinical decisions in diagnosis diabetes, gestational diabetes and impaired fasting glucose tolerance. Materials and methods Survey was performed in form of questionnaire. Questionn...
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1 week ago

Preanalytical, analytical and postanalytical considerations in circulating microRNAs measurement

Highlights • Methods used for miRNAs expression profiling are quantitative reverse transcription polymerase chain reaction, microarrays, next generation sequencing and droplet digital PCR • To obtain reproducible and accurate miRNAs expression profiling detection, it is crucial to strictly sta...
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1 week ago

Antiphospholipid antibodies in patients with antiphospholipid syndrome

Highlights • Antiphospholipid syndrome is a rare systemic autoimmune disease characterized by recurrent pregnancy morbidity or thrombosis in combination with the persistent presence of antiphospholipid antibodies in plasma/serum • Specialists in laboratory medicine should take responsibility f...
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1 week ago

Transcription factors organize into functional groups on the linear genome and in 3D chromatin

Transcription factors (TFs) and their binding sites have evolved to interact cooperatively or competitively with each other. Here we examine in detail, across multiple cell lines, such cooperation or competition among TFs both in sequential and spatial proximity (using chromatin conformation capture...
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2 years ago

Predicting the Oxidation States of Mn ions in the Oxygen Evolving Complex of Photosystem II Using Supervised and Unsupervised Machine Learning

Serial Femtosecond Crystallography at the X-ray Free Electron Laser (XFEL) sources enabled the imaging of the catalytic intermediates of the oxygen evolution reaction of Photosystem II. However, due to the incoherent transition of the S-states, the resolved structures are a convolution from diff...
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2 years ago

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