Biochemistry

Cell autocloning as a pathway to their real rejuvenation

The article gives a brief description of geroprotection and rejuvenation methods known to date, presenting their main mechanisms and limitations. To overcome the main limitations of the process of rejuvenation, it is possible to use a process called “cell autocloning.” The principle of the propo...
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5 days ago

The Challenge of Unlocking the Biological Secrets of Aging


5 days ago

MtDNA deletions and aging

<jats:p>Aging is the major risk factor in most of the leading causes of mortality worldwide, yet its fundamental causes mostly remain unclear. One of the clear hallmarks of aging is mitochondrial dysfunction. Mitochondria are best known for their roles in cellular energy generation, but they are als...
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5 days ago

Carbonic anhydrase production by Pseudomonas fragi


5 days ago

IFN-Aging: Coupling Aging With Interferon Response

Chronic inflammation affects many diseases and conditions, including aging. Interferons are a part of the immune defense against viral infections. Paradoxically, various aging tissues and organs from mammalian hosts perpetually accumulate changes brought by interferon pathway activation. Herein, we ...
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5 days ago

Aging Effects on Epicardial Adipose Tissue

Epicardial fat is the visceral fat of the heart. Epicardial fat is a white adipose tissue, but it displays also brown-fat like or beige fat features. Under physiological conditions, epicardial fat has cardioprotective functions such as free fatty acids supply and thermoregulation of the adjacent myo...
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5 days ago

Current and Potential Therapies Targeting Inflammation in NASH

Nonalcoholic steatohepatitis (NASH) is the advanced form of nonalcoholic fatty liver disease (NAFLD). It is characterized by hepatic steatosis, inflammation, hepatocellular injury, and fibrosis. Inflammation plays a key role in the progression of NASH and can be provoked by intrahepatic (e.g., lipot...
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5 days ago

Inflammatory Signaling and Brown Fat Activity


5 days ago

DHEAS and Human Development: An Evolutionary Perspective


5 days ago

Adipocyte-Endothelium Crosstalk in Obesity

Obesity is characterized by pathological adipose tissue (AT) expansion. While healthy AT expansion enhances systemic insulin sensitivity, unhealthy AT expansion through increased adipocyte size is associated with insulin resistance, fibrosis, hypoxia, and reduced adipose-derived adiponectin secretio...
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5 days ago

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