Key Questions
1. What is reversible cerebral vasoconstriction syndrome (RCVS)?
RCVS is characterized by diffuse, multifocal segmental narrowing of cerebral arteries that can result in ischemic stroke. It is often caused by immunosuppressant pharmacotherapy.
2. What are the common causes of RCVS in post-transplant patients?
RCVS is typically induced by immunotherapy drugs such as steroids and calcineurin inhibitors (e.g., tacrolimus, cyclosporine).
3. How is RCVS diagnosed?
Diagnosis is based on clinical symptoms such as severe headaches and transient neurological deficits, alongside imaging studies like cerebral angiography showing multifocal vasoconstriction.
4. What are the treatment options for RCVS?
Treatment focuses on removing the triggering agent (e.g., adjusting immunotherapy), along with supportive care like calcium channel blockers (e.g., nimodipine) to relieve vasospasm.
