Biomedical
Reduced immune system responsiveness in fibromyalgia - a pilot study
rnfinity
Sophia Bjorkander,
Ernberg Malin,
Ernberg Malin
Department of Dental Medicine, Karolinska Institutet, and the Scandinavian Centre for Orofacial Neurosciences (SCON),
Inders Bileviciute-Ljungar
Inders Bileviciute-Ljungar
Department of Rehabilitation Medicine, Danderyds University Hospital and Dept. of Clinical Sciences, Karolinska Institutet (KIDS),
Abstract
Fibromyalgia is characterized by widespread musculoskeletal and joint pain, stiffness, fatigue, and sleep and mood disorders. However, the involvement of the immune system in the pathways of fibromyalgia is unclear. The aim of this study was to explore the role of the immune system in comparison with healthy controls and in association with clinical symptoms. Thirteen women with fibromyalgia and 14 controls were included. Peripheral blood mononuclear cells were stimulated and analysed by flow cytometry, and interferon gamma (IFN-γ) and interleukins were measured. Among clinical symptoms, the fibromyalgia group showed decreased cold pain threshold. Immunologically, they had a higher percentage of monocytes, a lower percentage of CD19+ B-cells, and lower secretion of IFN-γ after stimulation. Decreased capacity to secrete IFN-γ was significantly correlated with decreased cold pain threshold in the fibromyalgia group. These results confirm the presence of immune aberrations in fibromyalgia, at least partially responsible for the associated pain.
Key Question
What is the main focus of this study?
The study explores the implications of climate change on cardiovascular health, with a focus on heatwaves, air pollution, and other environmental stressors.
How does climate change affect cardiovascular health?
Climate change exacerbates cardiovascular health risks through increased exposure to heatwaves, worsening air quality, and elevated stress on vulnerable populations.
What role does air pollution play in cardiovascular disease?
Air pollution, particularly fine particulate matter (PM2.5) and ozone, is linked to increased inflammation, oxidative stress, and a higher risk of cardiovascular events.
What populations are most vulnerable to climate-related cardiovascular risks?
Elderly individuals, those with pre-existing cardiovascular conditions, and low-income populations are particularly vulnerable to the effects of climate change on heart health.
What measures can mitigate the impact of climate change on cardiovascular health?
Strategies include improving air quality through emissions reductions, implementing public health measures during heatwaves, and raising awareness about climate-related health risks.
Why is this research important?
This research highlights the critical connection between environmental changes and cardiovascular health, emphasizing the need for interdisciplinary approaches to address these challenges.
