Research Infinity - All Articles

Biomedical

MtDNA deletions and aging

Aging is the major risk factor in most of the leading causes of mortality worldwide, yet its fundamental causes mostly remain unclear. One of the clear hallmarks of aging is mitochondrial dysfunction. Mitochondria are best known for their roles in cellular energy generation, but they are also critical biosynthetic and signaling organelles. They also undergo multiple changes with organismal...
Posted 2 months ago

Biomedical

Carbonic anhydrase production by Pseudomonas fragi

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Posted 2 months ago

Biomedical

IFN-Aging: Coupling Aging With Interferon Response

Chronic inflammation affects many diseases and conditions, including aging. Interferons are a part of the immune defense against viral infections. Paradoxically, various aging tissues and organs from mammalian hosts perpetually accumulate changes brought by interferon pathway activation. Herein, we connote the mechanisms behind this phenomenon and discuss its implications in age-related pathology....
Posted 2 months ago

Biomedical

Advancing longevity research through decentralized science

In an era marked by scientific stagnation, Decentralized Science (DeSci) challenges the inefficiencies of traditional funding and publishing systems. DeSci employs blockchain technology to address the misalignment of incentives in academic research, emphasizing transparency, rapid funding, and open-source principles. Centralized institutions have been linked to a deceleration of progress, which is...
Posted 2 months ago

Biomedical

Aging Effects on Epicardial Adipose Tissue

Epicardial fat is the visceral fat of the heart. Epicardial fat is a white adipose tissue, but it displays also brown-fat like or beige fat features. Under physiological conditions, epicardial fat has cardioprotective functions such as free fatty acids supply and thermoregulation of the adjacent myocardium. Epicardial adipose tissue encounters changes in the transition from embryological to childh...
Posted 2 months ago

Biomedical

An integrative approach to dementia care

As the aging population continues to increase, Alzheimer’s disease and related dementias are becoming a global health crisis. The burdens experienced by the person living with dementia, their caregivers, healthcare, and society persist unabated. Persons with dementia represent an important population in need of a tenable care plan. Caregivers need the tools with which to properly care for these ...
Posted 2 months ago

Biomedical

Aging, adaptation and maladaptation

Aging is accompanied by a dysregulation of adaptive processes. On the one hand, physiological adaptation mechanisms such as learning and memory, immune system plasticity and exercise-dependent muscle remodeling are blunted. On the other hand, several maladaptive processes increase with age including cancer, pathological cardiovascular remodeling and metabolic dysregulation. With increasing age the...
Posted 2 months ago

Physics Maths Engineering

Balancing predictability and flexibility through operation volume-constrained visual flight rule operations in low altitude airspaces

The advancement in uncrewed aircraft systems such as small drones and advanced air mobility vehicles such as Electric Vertical Take Off and Landing aircraft (eVTOL) has called for airspace integration at low altitudes of both traditional aircraft, such as helicopters and new entrants, such as drones and eVTOL. Currently, the trajectories and necessary buffers around them of flights operating under...
Posted 2 months ago

Physics Maths Engineering

Air traffic inefficiencies and predictability evaluation using route mapping—the Tokyo International Airport case

Air traffic inefficiencies lead to excess fuel burn, emissions and air traffic controller (ATCo) workload. Various stakeholders have developed metrics to assess the operation performance. Most metrics compare the actual trajectories to some benchmark ones to calculate excess time or distance. This research is inspired by cellular automata (CA) and develops a combined time-distance lateral ineffici...
Posted 2 months ago

Physics Maths Engineering

Model-based manoeuvre analysis: a path to a new paradigm in aircraft flight dynamics

We propose a closed-form system of nonlinear equations for the pitch plane or longitudinal motions of a fixed-wing aircraft and use it to demonstrate a possible path to the unification of theoretical flight dynamics and practical analysis of aircraft manoeuvres. The derivation of an explicit model free of data tables and interpolated functions is enabled by our use of empirical formulae for lift a...
Posted 2 months ago