AbstractBackgroundReproducibility is essential for the integrity of scientific research. Reproducibility is measured by the ability of different investigators to replicate the outcomes of an original publication using the same materials and procedures. Unfortunately, reproducibility is not current...
Posted 1 month ago
AbstractIn this critical review, we explore the study design, strengths and limitations of the paper: “Two-Year Outcomes of Sacral Neuromodulation Versus OnabotulinumtoxinA for Refractory Urgency Urinary Incontinence: A Randomized Trial.” The paper reports 24 month follow-up data of the landmark ROSETTA trial. This multi-centre, open-labelled parallel randomise...
Posted 1 month ago
AbstractBackgroundRadical prostatectomy (RP) has been considered primary treatment for localized prostate cancer. Biochemical recurrence (BCR) occur approximately 20–30% in five year after RP. We aim to develop a novel nomogram to predict BCR-free survival (BCRFS) and performed external validati...
Posted 1 month ago
AbstractBackgroundNephrocalcinosis is often asymptomatic but can manifest with renal colic or hematuria. There is no reported association between nephrocalcinosis and renal vascular malformations, which may also be a source of hematuria. We herein present a case of a patient with hematuria related...
Posted 1 month ago
AbstractBackgroundIncreased usage of cross sectional imaging for a variety of indications, in particular CT imaging, has led to an increased detection of renal and ureteric masses. Benign ureteric masses are rare, with 95% of identified tumours consisting of transitional cell carcinoma (TCC). IgG4...
Posted 1 month ago
AbstractIn this critical review, we explore the study design, strengths, and limitations of landmark trial “Anticholinergic therapy vs. onabotulinumtoxinA for urgency urinary incontinence”. This trial was the first to directly compare two key treatment options for urge urinary incontinence – anticholinergic medication and intravesical botox, and still influen...
Posted 1 month ago
Institute for Environment and Human Security, United Nations University, UN Campus, Platz der Vereinten Nationen 1, 53113 Bonn, Germany
Stefan Mönnich,
Stefan Mönnich
Institute for Environment and Human Security, United Nations University, UN Campus, Platz der Vereinten Nationen 1, 53113 Bonn, Germany
Thecla Akukwe
Thecla Akukwe
Department of Geography, University of Nigeria, Nsukka 410001, Nigeria
The evidence for the capacity of mangrove forests for coastal protection gained more importance within the recent decade because of important international agreements, such as the Sustainable Development Goals and Sendai Framework for Disaster Risk Reduction. However, the degree to which researchers agree on the capacity of mangroves to reduce coastal hazards is not fully established. This...
Posted 1 month ago
Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London SE5 8AF, UK
Nefize Yalin,
Nefize Yalin
Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London SE5 8AF, UK
Stelios Orfanos,
Stelios Orfanos
South London & Maudsley NHS Foundation Trust, Maudsley Hospital, Denmark Hill, London SE5 8AZ, UK
Allan H. Young
Allan H. Young
Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London SE5 8AF, UK
Acetazolamide, a carbonic anhydrase inhibitor, is used to treat a variety of ailments. It has been highlighted for its potential to benefit people with bipolar disorders, for whom there are clear current unmet treatment needs. This scoping review sought to synthesise all available evidence related to the potential effects of acetazolamide on symptoms related to bipolar disorder, acceptabil...
Posted 1 month ago