Progress on Electrochemical Sensing of Pharmaceutical Drugs in Complex Biofluids

Key Questions about Electrochemical Drug Sensing in Biofluids

The article "Progress on Electrochemical Sensing of Pharmaceutical Drugs in Complex Biofluids" reviews advancements in electrochemical sensors designed to detect pharmaceutical drugs within complex biological fluids such as saliva, sweat, interstitial fluid, urine, and blood/serum. These biofluids present challenges due to their diverse compositions, which can interfere with accurate drug detection. The review emphasizes the importance of developing sensitive and selective electrochemical sensors to improve therapeutic drug monitoring and patient care.

1. What challenges do complex biofluids pose for electrochemical drug sensing?

Complex biofluids contain multiple components that can contribute to increased background signals or reduced analyte signals, complicating the detection of pharmaceutical drugs.

2. How can electrochemical sensors be optimized for drug detection in these fluids?

Advancements in sensor design, including the use of nanomaterials and selective recognition elements, have enhanced the sensitivity and selectivity of electrochemical sensors, making them more effective for drug detection in complex biofluids.

3. What is the significance of improving therapeutic drug monitoring?

Enhanced drug monitoring allows for more precise dosing, reducing the risk of adverse effects and improving patient outcomes.

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