Biomedical
Diagnostic role of urine human epididymis protein 4 in ovarian cancer
Peer Reviewed
Abstract
Urine human epididymis protein 4 (HE4) is a promising, non-invasive tumor marker for ovarian cancer (OC), offering advantages in early detection and monitoring. Studies show urine HE4 concentrations are higher than serum levels, with comparable sensitivity and specificity for detecting OC. It can aid in the differential diagnosis, monitor chemotherapy response, and track disease recurrence. However, standardization of HE4 detection methods is necessary for clinical application. Urine samples are more accessible, enabling easier and more frequent monitoring compared to blood tests.
Key Questions and Answers
1. What is the role of urine HE4 in ovarian cancer diagnosis?
Urine HE4 serves as a non-invasive tumor marker for early diagnosis, monitoring chemotherapy response, and detecting recurrence in ovarian cancer patients.
2. Why is urine HE4 advantageous over other diagnostic methods?
Urine HE4 offers a higher concentration than serum and can be measured easily and repeatedly without patient health limitations, unlike blood tests.
3. What is the need for standardization in urine HE4 detection?
Standardizing detection methods is crucial before urine HE4 can be widely implemented in clinical practice to ensure reliable results.
