Biomedical
Peer Reviewed
Nonalcoholic steatohepatitis (NASH) is the advanced form of nonalcoholic fatty liver disease (NAFLD). It is characterized by hepatic steatosis, inflammation, hepatocellular injury, and fibrosis. Inflammation plays a key role in the progression of NASH and can be provoked by intrahepatic (e.g., lipotoxicity, immune responses, oxidative stress and cell death) and extrahepatic sources (adipose tissue or gut). The identification of triggers of inflammation is central to understanding the mechanisms in NASH development and progression and in designing targeted therapies that can halt or reverse the disease. In this review, we summarize the current and potential therapies targeting inflammation in NASH.
Nonalcoholic steatohepatitis (NASH) is the advanced form of nonalcoholic fatty liver disease (NAFLD). It is characterized by hepatic steatosis, inflammation, hepatocellular injury, and fibrosis. Inflammation plays a key role in the progression of NASH and can be provoked by intrahepatic sources such as lipotoxicity, immune responses, oxidative stress, and cell death, as well as extrahepatic sources like adipose tissue or the gut. :contentReference[oaicite:1]{index=1}
Inflammation in NASH is driven by the interplay between hepatocytes, hepatic stellate cells, and recruited immune cells. This inflammatory response leads to hepatocellular injury, fibrosis, and ultimately cirrhosis, liver-related complications, end-stage liver disease, and the need for liver transplantation. :contentReference[oaicite:2]{index=2}
Current therapeutic strategies targeting inflammation in NASH include lifestyle modifications such as weight loss and dietary changes, as well as pharmacological interventions aimed at reducing hepatic inflammation and fibrosis. These treatments aim to halt or reverse the progression of NASH and prevent complications like cirrhosis and liver cancer. :contentReference[oaicite:3]{index=3}
Potential therapies being explored for NASH include anti-inflammatory agents, antifibrotic drugs, and agents targeting specific metabolic pathways involved in the disease. These therapies aim to address the underlying mechanisms of NASH and offer hope for more effective treatments in the future. :contentReference[oaicite:4]{index=4}
Show by month | Manuscript | Video Summary |
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2025 April | 3 | 3 |
2025 March | 57 | 57 |
2025 February | 42 | 42 |
2025 January | 38 | 38 |
2024 December | 51 | 51 |
2024 November | 48 | 48 |
2024 October | 15 | 15 |
Total | 254 | 254 |
Show by month | Manuscript | Video Summary |
---|---|---|
2025 April | 3 | 3 |
2025 March | 57 | 57 |
2025 February | 42 | 42 |
2025 January | 38 | 38 |
2024 December | 51 | 51 |
2024 November | 48 | 48 |
2024 October | 15 | 15 |
Total | 254 | 254 |