Biomedical
Epicardial fat is the visceral fat of the heart. Epicardial fat is a white adipose tissue, but it displays also brown-fat like or beige fat features. Under physiological conditions, epicardial fat has cardioprotective functions such as free fatty acids supply and thermoregulation of the adjacent myocardium. Epicardial adipose tissue encounters changes in the transition from embryological to childhood and then to adult life. Aging can affect the function and morphology of epicardial fat, more likely in women than in men. The effect of aging on the brown fat properties of the epicardial fat is the most prominent and with the greatest clinical implications. It is promising to know that epicardial fat responds to newer pharmaceutical drugs modulating the adipose tissue and potentially restoring its browning effects. Epicardial fat pro-inflammatory secretome is down-regulated in end-stage coronary artery disease. Chronic ischemia and adverse hemodynamic conditions can also affect the regulatory component of the epicardial fat. Epicardial fat may incur in apoptotic and fibrotic changes that alter its transcriptome and proteasome. In conclusion, aging and advanced stage of chronic diseases are likely to influence and affect epicardial fat genes and function
Epicardial fat is the visceral fat of the heart, located between the myocardium and the visceral layer of the epicardium. It serves physiological functions such as supplying the myocardium with energy and thermoregulation. :contentReference[oaicite:1]{index=1}
Aging can lead to apoptotic and fibrotic changes in epicardial fat, altering its transcriptome and proteasome. These changes may impair its physiological functions and contribute to cardiovascular diseases. :contentReference[oaicite:2]{index=2}
Understanding how aging affects epicardial fat can help in developing strategies to maintain its function and prevent cardiovascular diseases associated with aging. Further research is needed to explore interventions that can mitigate these age-related changes. :contentReference[oaicite:3]{index=3}
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Show by month | Manuscript | Video Summary |
---|---|---|
2025 April | 1 | 1 |
2025 March | 60 | 60 |
2025 February | 41 | 41 |
2025 January | 41 | 41 |
2024 December | 47 | 47 |
2024 November | 49 | 49 |
2024 October | 17 | 17 |
Total | 256 | 256 |