Biomedical
Metabolic alkalosis and mortality in COVID-19
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Zhifeng Jiang
Zhifeng Jiang
University of Science and Technology; No.6, Square street, Xiaonan District, Xiaogan 5 City,
Abstract
Abstract Background As a new infectious disease affecting the world, COVID-19 has caused a huge impact on countries around the world. At present, its specific pathophysiological mechanism has not been fully clarified. We found in the analysis of the arterial blood gas data of critically ill patients that the incidence of metabolic alkalosis in such patients is high. Method We retrospectively analyzed the arterial blood gas analysis results of a total of 16 critically ill patients in the intensive ICU area of Xiaogan Central Hospital and 42 severe patients in the intensive isolation ward, and analyzed metabolic acidosis and respiratory acidosis. Metabolic alkalosis and respiratory alkalosis, and the relationship between metabolic alkalosis and death. Result Among the 16 critically ill patients, the incidence of metabolic alkalosis was 100%, while the incidence of metabolic alkalosis in severe patients was 50%; the mortality rate in critically ill patients was 81.3%, and 21.4% in severe patients ; The mortality of all patients with metabolic alkalosis is 95.5%,and 4.5% in without metabolic alkalosis. Conclusion The incidence of metabolic alkalosis in critically ill COVID-19 patients is high, and it is associated with high mortality. Key words :COVID-19, Metabolic alkalosis, mortality
Key Questions
What is the focus of the article "Metabolic alkalosis and mortality in COVID-19"?
The article investigates the relationship between metabolic alkalosis (a condition where the body has an excess of bicarbonate or a loss of acid) and mortality in patients with COVID-19, focusing on how this metabolic disturbance may influence patient outcomes.
What is metabolic alkalosis and how is it related to COVID-19?
Metabolic alkalosis is a condition in which the body’s pH level becomes abnormally high due to an imbalance in acid-base regulation. The article explores how COVID-19 patients may develop this condition and whether it has any association with higher mortality rates in critically ill patients.
How does metabolic alkalosis impact COVID-19 patient outcomes?
The study finds that metabolic alkalosis may be associated with worse outcomes in COVID-19 patients, potentially increasing mortality risk. This connection underscores the importance of monitoring and managing acid-base imbalances in critical care for these patients.
What were the key findings of the article regarding metabolic alkalosis and mortality?
The article identifies a significant association between the presence of metabolic alkalosis and higher mortality rates in COVID-19 patients, particularly those who require intensive care. This suggests that metabolic disturbances should be closely monitored in COVID-19 management.
What role does bicarbonate play in metabolic alkalosis in COVID-19 patients?
Bicarbonate levels are a key factor in metabolic alkalosis. In COVID-19 patients, elevated bicarbonate levels are linked to the condition, and managing bicarbonate levels may be an important consideration in improving patient prognosis.
What recommendations does the article make for healthcare providers?
The article recommends that healthcare providers closely monitor acid-base balance, including bicarbonate levels, in critically ill COVID-19 patients. Early detection and correction of metabolic alkalosis may improve patient outcomes and reduce the risk of mortality.
What are the implications for future research on metabolic alkalosis in COVID-19?
Future research could further explore the mechanisms behind metabolic alkalosis in COVID-19 patients and evaluate targeted treatments for correcting acid-base imbalances to enhance survival rates, particularly in severe cases.
