Biomedical
Is manual drawing of region of interest to measure fractional anisotropy a reliable method of determining white matter integrity- Medial Temporal Lobe Epilepsy model
Saman Hazany,
Saman Hazany
Institution: Keck School of Medicine of USC Radiology Department, Neuroradiology Division,
Email: samanh26@gmail.com
Brittany DeClouette
Abstract
In patients with Medial Temporal Lobe Epilepsy (MTLE), more severe impairment in the ipsilateral than the contralateral hemisphere white matter tracts, including Superior Longitudinal Fasciculus (SLF), are demonstrated on diffusion tensor imaging (DTI). Many clinicians and researchers conclude that drawing regions of interest (ROI) in the white matter can demonstrate these asymmetries. In this study we demonstrate that fractional anisotropy (FA) values derived from manually drawing ROI’s on diffusion tensor imaging (DTI) of SLF differ between the side of seizure onset compared to the contralateral side in each individual patient with MTLE does not demonstrate these previous conclusions. We therefore believe that clinicians should recognize that this method of measurement can be inaccurate and should not be interpreted independently
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Article usage: Mar-2022 to Nov-2024
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| Total | 885 | 885 |
| Show by month | Manuscript | Video Summary |
|---|---|---|
| 2024 November | 39 | 39 |
| 2024 October | 48 | 48 |
| 2024 September | 54 | 54 |
| 2024 August | 31 | 31 |
| 2024 July | 38 | 38 |
| 2024 June | 28 | 28 |
| 2024 May | 45 | 45 |
| 2024 April | 54 | 54 |
| 2024 March | 31 | 31 |
| 2024 February | 3 | 3 |
| 2024 January | 5 | 5 |
| 2023 December | 6 | 6 |
| 2023 November | 2 | 2 |
| 2023 October | 2 | 2 |
| 2023 September | 4 | 4 |
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| 2023 May | 12 | 12 |
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| 2023 March | 18 | 18 |
| 2023 February | 1 | 1 |
| 2023 January | 3 | 3 |
| 2022 December | 26 | 26 |
| 2022 November | 68 | 68 |
| 2022 October | 33 | 33 |
| 2022 September | 30 | 30 |
| 2022 August | 46 | 46 |
| 2022 July | 51 | 51 |
| 2022 June | 96 | 96 |
| 2022 May | 43 | 43 |
| 2022 April | 28 | 28 |
| 2022 March | 19 | 19 |
| Total | 885 | 885 |
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