Research Infinity - All Articles

Biomedical

Controversies in Neurology: why monoamine oxidase B inhibitors could be a good choice for the initial treatment of Parkinson's disease

The article "Controversies in Neurology: why monoamine oxidase B inhibitors could be a good choice for the initial treatment of Parkinson's disease" examines the potential benefits of initiating treatment with monoamine oxidase B (MAO-B) inhibitors in early-stage Parkinson's disease (PD). The authors discuss the favorable safety profile and possible neuroprotective effects of MAO-B inhibitors, ...
Posted 4 months ago

Biomedical

Prevalence of sleep disorders in Parkinson’s disease patients in two neurology referral hospitals in Ethiopia

The article "Prevalence of sleep disorders in Parkinson’s disease patients in two neurology referral hospitals in Ethiopia" investigates the prevalence of sleep disorders among Parkinson's disease (PD) patients in Ethiopia. The study found that all 155 surveyed patients reported some form of sleep problem, with over 43.9% scoring above 18 on the Parkinson's Disease Sleep Scale (PDSS-2), indic...
Posted 4 months ago

Biomedical

Synesthesia and Migraine: Case Report

The article "Synesthesia and Migraine: Case Report" presents a unique case of a 40-year-old woman with a cyclic mood disorder who experienced synesthetic sensations exclusively during visual migraine auras. Specifically, she reported an intense taste of lemon accompanied by salivation when staring at bright light during the aura phase. This case supports the hypothesis of anomalous cortical pro...
Posted 4 months ago

Biomedical

Methodological quality of guidelines for management of Lyme neuroborreliosis

Background; Many aspects of clinical management of Lyme neuroborreliosis are subject to intense debates. Guidelines show considerable variability in their recommendations, leading to divergent treatment regimes. The most pronounced differences in recommendations exist between guidelines from scientific societies and from patient advocacy groups. Assessment of the methodological quality of these c...
Posted 4 months ago

Biomedical

Pediatric multiple sclerosis: a review

Background Pediatric-onset multiple sclerosis (POMS) prevalence and incidence rates are increasing globally. No disease-modifying therapy are approved for MS pediatric population. Hence, we aim to review the literature on POMS to guide treating physicians on the current understanding of diagnosis and management of pediatric MS. Methods The authors performed a literature search and reviewed th...
Posted 4 months ago

Biomedical

Neuroinflammation and Brain Disease

Abstract

Starting from the perspective of an immune-privileged site, our knowledge of the inflammatory processes within the central nervous system has increased rapidly over the last 30 years, leading to a rather puzzling picture today. Of particular interest is the emergence of disease- and injury-specific inflammatory responses within t...
Posted 4 months ago

Biomedical

Stroke in young adults, stroke types and risk factors: a case control study

Abstract Background Stroke is the second leading cause of death above the age of 60 years, and the fifth leading cause in people aged 15 to 59 years old as reported by the World Health Organization global burden of diseases. Stroke in the young is particularly tragic because of the potential to ...
Posted 4 months ago

Biomedical

Meeting the unique challenges of drug discovery for neurodegenerative diseases

The article "Meeting the unique challenges of drug discovery for neurodegenerative diseases" discusses the complexities and opportunities in developing therapeutics for conditions such as Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, and multiple sclerosis. The authors emphasize the need for a multidisciplinary approach, integrating academic rese...
Posted 4 months ago

Biomedical

The basics of preclinical drug development for neurodegenerative disease indications

The article "The basics of preclinical drug development for neurodegenerative disease indications" provides an overview of the essential steps involved in transitioning a drug candidate from laboratory discovery to human clinical trials. It emphasizes the importance of preclinical studies in identifying lead candidates, developing scalable production methods, selecting optimal formulations, and...
Posted 4 months ago

Biomedical

Characteristics of compounds that cross the blood-brain barrier

The article "Characteristics of compounds that cross the blood-brain barrier" discusses the mechanisms by which substances traverse the blood-brain barrier (BBB), focusing on transmembrane diffusion and transporters. It highlights that transmembrane diffusion is non-saturable and depends on the physicochemical properties of the substance. Additionally, the article notes that brain-to-blood effl...
Posted 4 months ago